On tumor formation in gonadal and hypophyseal transplants into the anterior eye chambers of gonadectomized rats.

Small pieces of ovarian, testicular, or ovarian plus hypophyseal tissue were transplanted to the anterior eye chambers of rats, aged ~ months, which were simultaneously gonadeetomized. One year after the operations the animals were examined. The ovarian and testieular grafts had taken and had been t ransformed to tumors in a very high percentage of cases. The ovarian and testieular tumors were morphologically similar to each other, and both had estrogenic as well as androgenic properties. Ovarian and hypophyseal grafts in the same eye grew rapidly into large tumors (granulosacell tumors and ehromophobie hypophyseal adenonms), with signs of progesterone and prolaetin secretion, respectively. One of the animals had a m a m m a r y adenocarcinoma, and the m a m m a r y glands in all were highly st imulated and secreting milk. I t is concluded tha t prolactin may stimulate the growth and influence the secretion of granulosa-cell tumors. Gonadal and m a m m a r y tumors are discussed in relation to the experimental results.